CCR1, C-C motif chemokine receptor 1

CCR1, C-C motif chemokine receptor 1

• This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008]

• Gene Synonyms (C-C chemokine receptor type 1, C-C CKR-1, CC-CKR-1, CCR-1, LD78 receptor, MIP-1alpha-R, RANTES receptor, RANTES-R, chemokine (C-C motif) receptor 1, macrophage inflammatory protein 1-alpha receptor, CD191, CKR-1, CKR1, CMKBR1, HM145, MIP1aR, SCYAR1,)
• NCBI Gene ID: 1230
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q5U003
  UNIPROT ID#>>P32246
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

C-C motif chemokine receptor 1 interacts with:

• cAMP responsive element binding protein 3
  C-C motif chemokine ligand 14
  C-C motif chemokine ligand 15
  C-C motif chemokine ligand 16
  C-C motif chemokine ligand 2
  C-C motif chemokine ligand 23
  C-C motif chemokine ligand 26
  C-C motif chemokine ligand 3
  C-C motif chemokine ligand 3 like 1
  C-C motif chemokine ligand 4
  C-C motif chemokine ligand 5
  C-C motif chemokine ligand 7
  C-C motif chemokine ligand 8
  C-C motif chemokine receptor 1
  cell division cycle associated 3
  chromosome 12 open reading frame 75
  EPH receptor A2
  G protein subunit alpha 13
  G protein subunit alpha 14
  G protein subunit alpha q
  G protein subunit gamma 10
  growth associated protein 43
  Janus kinase 1
  late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
  leukocyte receptor cluster member 1
  phosphoprotein membrane anchor with glycosphingolipid microdomains 1
  proteolipid protein 2
  SET domain containing 7, histone lysine methyltransferase
  signal transducer and activator of transcription 1
  signal transducer and activator of transcription 3
  syntaxin binding protein 2
  thioredoxin related transmembrane protein 1
  tyrosylprotein sulfotransferase 1
  tyrosylprotein sulfotransferase 2
  YES proto-oncogene 1, Src family tyrosine kinase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.