ADD1, adducin 1

ADD1, adducin 1

• Adducins are a family of cytoskeletal proteins encoded by three genes (alpha, beta, and gamma). Adducin acts as a heterodimer of the related alpha, beta, or gamma subunits. The protein encoded by this gene represents the alpha subunit. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. [provided by RefSeq, Aug 2017]

• Gene Synonyms (ADDA, alpha-adducin, adducin 1 (alpha), erythrocyte adducin alpha subunit,)
• NCBI Gene ID: 118
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P35611
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

adducin 1 interacts with:

• adducin 2
  adducin 3
  ankyrin repeat domain 29
  atlastin GTPase 2
  ATPase Na+/K+ transporting subunit alpha 1
  cadherin 1
  calmodulin 1
  capping actin protein of muscle Z-line subunit alpha 2
  casein kinase 2 beta
  caspase 3
  CDKN2A interacting protein
  chromosome 1 open reading frame 109
  coronin, actin binding protein 1C
  cyclin dependent kinase 9
  developmental pluripotency associated 4
  dynein cytoplasmic 1 intermediate chain 2
  dynein light chain Tctex-type 1
  dystonin
  estrogen receptor 2
  exportin 1
  family with sequence similarity 78 member A
  gem nuclear organelle associated protein 7
  guanylate binding protein 2
  heat shock protein family H (Hsp110) member 1
  heat shock transcription factor 2 binding protein
  heparan sulfate proteoglycan 2
  high mobility group 20A
  histone deacetylase 1
  HRas proto-oncogene, GTPase
  inhibitor of DNA binding 2
  inhibitor of DNA binding 3, HLH protein
  interferon gamma inducible protein 16
  inverted formin 2
  IQ motif containing GTPase activating protein 1
  kelch like family member 42
  KRAS proto-oncogene, GTPase
  leucine rich repeats and WD repeat domain containing 1
  LIM domain and actin binding 1
  lysosomal associated membrane protein 1
  microtubule associated protein 1 light chain 3 beta
  microtubule associated protein RP/EB family member 1
  MMS19 homolog, cytosolic iron-sulfur assembly component
  myosin IC
  myosin IC
  myosin, heavy polypeptide 9, non-muscle
  nestin
  neurotrophic receptor tyrosine kinase 1
  NRAS proto-oncogene, GTPase
  nuclear receptor subfamily 2 group C member 2
  nucleoporin 54
  pleckstrin homology domain containing A4
  protein kinase C alpha
  protein kinase C delta
  protein kinase cAMP-activated catalytic subunit alpha
  pyruvate dehydrogenase E1 subunit alpha 1
  regulatory factor X1
  replication protein A1
  replication protein A2
  replication protein A3
  Rho associated coiled-coil containing protein kinase 1
  ring finger protein 138
  ring finger protein 144A
  SIN3 transcription regulator family member A
  spectrin alpha, erythrocytic 1
  spectrin alpha, non-erythrocytic 1
  spectrin beta, erythrocytic
  spectrin beta, non-erythrocytic 1
  supervillin
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
  thymidine kinase 1
  tripartite motif containing 25
  tropomodulin 1
  tropomodulin 3
  tropomyosin 2
  tropomyosin 3
  tropomyosin 4
  tropomyosin 4
  UbiA prenyltransferase domain containing 1
  valosin containing protein
  zinc finger DHHC-type palmitoyltransferase 17

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.