Expression of the RET receptor tyrosine kinase and GDNFR-alpha in normal and leukemic human hematopoietic cells and stromal cells of the bone marrow microenvironment.
Gattei, V., Celetti, A., Cerrato, A., Degan, M., De Iuliis, A., Rossi, F.M., Chiappetta, G., Consales, C., Improta, S., Zagonel, V., Aldinucci, D., Agosti, V., Santoro, M., Vecchio, G., Pinto, A. and Grieco, M.
Notes: Acute myeloid leukemia cells expressing RET were assayed for clonogenic growth of blast cells by GDNF with or without treatment with a phosphoinositol-specific phospholipase C. The GDNFR-alpha is phosphoinositol-linked protein. Cells were also treated with GDNF, reacted with the anti-GDNF antibody and reacted with the FITC-conjugated Anti-chicken IgY. The cells were analyzed by flow cytometry in the presence or absence of the phospholipase C. (1573)
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