Kuhnel, F., Zender, L., Paul, Y., Tietze, M.K., Trautwein, C., Manns, M., Kubicka, S.
Notes: The CaspACE™ Assay System was used to analyze caspase-3 activation of the mouse liver homogenates derived from mice infected with adenoviruses expressing either β-galactosidase or IκBα. Adenovirus infection activates NF-κB, which in turn increases Fas expression and eventually leads to increased apoptosis. The IκBα delayed the onset of apoptosis in the 2- to 8-hour range. (It is not clear whether the authors used the CaspACE™ Assay System, Fluorometric, or CaspACE™ Assay System, Colorimetric, by the description in the paper). (0857)