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Proc. Natl. Acad. Sci. USA 103, 16556-16561. Acid-sensing ion channel 1a is a postsynaptic proton receptor that affects the density of dendritic spines. 2006

Zha, X-m., Wemmie, J.A., Green, S.H. and Welsh, M.J.

Notes: Acidification can occur during synaptic nerve impulse transmission when the synaptic vesicles empty their contents into the synapse. The authors of this study investigated the role of protons in ion channel regulation at the synapse. They identified the acid-sensing ion channel 1a (ASIC1a) as a proton receptor, and they investigated its relationship to activation of the Ca2+/calmodulin-dependent protein kinase (CaM KII). Anti-ACTIVE® CaM KII pAb was used for Western analysis of immunoprecipitated CaM KII from wildtype or ASIC1a-knockout mouse brains. (3549)

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J. Neurosci. 26, 4198-4205. Pathway-specific bidirectional regulation of Ca2+/calmodulin-dependent protein kinase II at spinal nociceptive synapses after acute noxious stimulation. 2006

Larsson, M. and Broman, J.

Notes: The authors of this study investigated the role of CaM KII in the induction of NMDA receptor-dependent sensitization of dorsal horn neurons. Ultrathin dorsal horn sections from capsaicin-injected and control rats were fixed and embedded and then incubated with Anti-ACTIVE® CaM KII pAb. After washing, sections were incubated with goat anti-rabbit secondary antibody conjugated to 10nm colloidial gold. (3548)

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Proc. Natl. Acad. Sci. USA 102, 9400-9405. α1-Adrenoceptor stimulation potentiates L-type Ca2+ current through Ca2+/calmodulin-dependent PK II (CaMKII) activation in rat ventricular myocytes. 2005

O-Uchi, J., Komukai, K., Kusakari, Y., Obata, T., Hongo, K., Sasaki, H. and Kurihara, S.

Notes: Whole-cell extracts were prepared from rat ventricular myocytes treated with various concentrations of phenylephrine. Activation of CaMKII was assessed by Western analysis using Anti-ACTIVE® CaMKII pAb. Anti-ACTIVE® CaMKII pAb was also used to localize phosphorylated CaMKII by immunofluorescence microscopy of ventricular myocytes. Anti-ACTIVE® CaMKII pAb and 15nm gold-conjugated goat anti-rabbit IgG secondary antibodies were used to perform immunoelectron microscopy of isolated myocytes to further determine the subcellular localization of activated CaMKII. (3435)

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Neuron 36, 483–491. Autophosphorylation of αCaMKII is required for ocular dominance plasticity. 2002

Taha, S., Hanover, J.L., Silva, A.J. and Stryker, M.P.

Notes: Anti-ACTIVE® CaM KII pAb was used to detect phosphorylated CAM KII by immunohistochemistry and Western blot analysis in tissues isolated from transgenic mice. A 1:200 dilution of the Anti-ACTIVE® CaM KII pAb was used in conjunction with an immunoperoxidase detection kit for immunohistochemical analysis.  For Western blot analysis, a 1:5000 dilution of the antibody was used.  (3202)

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J. Neurosci. 22, 3788-3794. Priming of long-term potentiation in mouse hippocampus by corticotropin-releasing factor and acute stress: implications for hippocampus-dependent learning.  2002

Blank, T., Nijholt, I., Eckart, K. and Spiess, J.

Notes: This paper studied the effects of both acute stress and Corticotropin-releasing factor (CRF) on hippocampus-dependent learning and on long-term synaptic plasticity in the mouse hippocampus.  In particular, the roles of PKC and CaMKII in the regulation of hippocampal long-term synaptic plasticity and in the performance of mice in a hippocampus-dependent learning task were studied. The level of active CaM KII in mouse hippocampal extracts was investigated by western blotting using the Anti-ACTIVE™ CaM KII antibody.  (2765)

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J. Neurochem. 76, 149-54. Autonomous activity and autophosphorylation of CAMPK-II in rat hippocampal slices: Effects of tissue preparation. 2001

Lengyel, I., Cammarota, M., Brent, V.A., and Rostas, J.A.

Notes: The authors show how certain common tissue handling techniques, such as equilibration for 1-2 hours in a physiological medium and freezing, can dramatically affect the level of autonomous CaM KII activity in hippocampal tisuse, leading to potential artefacts in data. Activation of Cam KII was monitored by Western blot analysis using the Anti-ACTIVE® CaM KII pAb primary antibody. (2408)

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J. Biol. Chem. 276, 40811-6. Different subtypes of alpha1-adrenoceptor modulate different K+ currents via different signaling pathways in canine ventricular myocytes. 2001

Wang, H., Yang, B., Zhang, Y., Han, H., Wang, J., Shi, H., and Wang, Z.

Notes: The signal transduction mechanisms of adrenoreceptors in regulating K+ currents in isolated canine ventricular myocytes and human embryonic kidney (HEK 293) cells were examined. The CamKII pathway was monitored in the presence or absence of a specific inhibitor CaM KII inhibitor by Western blot using the Anti-ACTIVE® CaM KII pAb. (2407)

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J. Biol. Chem. 275(17), 12701-12711. Ca2+/Calmodulin-dependent Protein Kinase II Is Stimulated by Wnt and Frizzled Homologs and Promotes Ventral Cell Fates in Xenopus 2000

Kuhl, M., Sheldahl, L.C., Malbon, C.C., and Moon, R.T.

Notes: Xenopus embryos were split into dorsal and ventral halves at stage 7. The total CaM KII was immunoprecipitated then blotted with the Anti-ACTIVE® CaM KII pAb. Both halves had activated CaM KII but the ventral portion displayed a greater increase in phosphorylation. Stripping and reprobing the membranes with a normal CaM KII antibody demonstrated that equal amounts of CaM KII were present in the two samples. (0070)

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Proc. Natl. Acad. Sci. USA 97, 11232-7. Involvement of neurogranin in the modulation of calcium/calmodulin-dependent protein kinase II, synaptic plasticity, and spatial learning: a study with knockout mice. 2000

Pak, J.H., Huang, F.L., Li, J., Balschun, D., Reymann, K.G., Chiang, C., Westphal, H., and Huang, K.P

Notes: Neurogranin deficient mice did not exhibit developmental or neuroanatomical abnormalities but had deficits in learning and memory. The levels of phosphorylated CaM KII in hippocampal extracts was determined by quantitative immunoblotting using the Anti-ACTIVE® CamKII pAb. (2410)

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J. Neurophysiol. 82, 1560-1568.. Angiotensin II decreases neuronal delayed rectifier potassium current: Role of calcium/calmodulin-dependent protein kinase II 1999

Zhu, M., Gelband, C.H., Posner, P., Sumners, C.

Notes: The presence of autophosphorylated CaM KII in control or angiotensin II-treated neuronal cultures made from Sprague-Dawley rats was determined by Western blotting with a 1:5000 dilution of the Anti-ACTIVE® CaMKII pAb. Cell Extracts were made with a buffer containing 1% NP-40, 10% glycerol, 150 mM NaCl, 20 mM Tris-HCl and protease inhibitors. (0063)

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Proc. Natl. Acad. Sci. USA 95, 10890-10895. Characterization of a calmodulin kinase II inhibitor protein in brain. 1998

Chang, B.H., Mukherji, S. and Soderling, T.R.

Notes: The Anti-ACTIVE® CaM KII pAb was used to detect phospho-T286 of rat calmodulin kinase II in COS-7 cells by immunocytochemistry. Good detail is provided for the immunocytochemistry protocol. (1359)

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