J. Biol. Chem.
Glycogen synthase kinase-3beta phosphorylates protein tau and rescues the axonopathy in the central nervous system of human four-repeat tau transgenic mice.
Spittaels, K., Van den Haute, C., Van Dorpe, J., Geerts, H., Mercken, M., Bruynseels, K., Lasrado, R., Vandezande, K., Laenen, I., Boon, T., Van Lint, J., Vandenheede, J., Moechars, D., Loos, R., and Van Leuven, F.
Notes: Hyperphosphorylation of protein tau in the brain has been linked to Alzheimer's disease. The level of phosphorylated and unphosphorylated protein tau in brains and spinal cords of transgenic mice expressing a protein tau kinase, was quantified by Western blots. Western blot results for protein tau were normalized for tubulin using the Anti-βIII Tubulin mAb. (2357)
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