Zhang, Y., Lemasters, J., Herman, B.
Notes: This paper investigated the role of group IIA phospholipase A2 (PLA2) in apoptosis and sought to identify its subcellular target. Baby hamster kidney fibroblasts (BHK) were transfected with wildtype or mutant rat PLA2, subjected to growth factor deprivation, and were assayed for survival. Cells expressing either no PLA2 or mutant PLA2 underwent dramatic apoptosis; cells expressing the wildtype PLA2 showed resistance to apoptosis. The CellTiter 96® AQueous One Solution Cell Proliferation Assay was used to determine cell viability of the BHK cells. (2481)