Clin. Can. Res.
MSH6 and MUTYH deficiency is a frequent event in early-onset colorectal cancer.
Giráldez, M.D., Balaguer, F., Bujanda, L., Cuatrecasas, M., Muñoz, J., Alonso-Espinaco, V., Larzabal, M., Petit, A., Gonzalo, V., Ocaña, T., Moreira, L., Enríquez-Navascués, J.M., Boland, C.R., Goel, A., Castells, A. and Castellví-Bel, S.
Notes: To better understand early onset colorectal cancer (CRC), the researchers examined mismatch repair (MMR) deficiency by analyzing microsatellite instability (MSI) of five mononucleotide markers BAT25, BAT26, NR21, NR24, and MONO27 from tumors using the MSI Analysis System, Version 1.2. Instability at ≥3 markers classified the tumors as high MSI, while those unstable at ≤2 markers were designated as microsatelite stable. These results were compared with immunostaining analysis of MMR proteins. (4113)
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