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Promega Corporation

GPCR Assays

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GPCR Assays Resources

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Monitor GPCR Pathways

G-protein-coupled receptors (GPCR) represent one of the most important classes of drug targets. Major G-protein families signal via second messengers like cAMP, which in turn, activate a range of effector systems to change cell behavior, gene transcription. Promega offers assays, such as the GloSensor™ cAMP Assay that can monitor second messenger activity, as well as sensitive reporter assays that can monitor activity of response elements or target genes.

Featured Products

Live-Cell Biosensor for GPCR Studies

Obtain data directly from living cells with the GloSensor™ cAMP Assay is a 'zero step' assay for studies on cAMP kinetics.

Custom Assay Services

Let us partner with you to develop a complete biology-driven, Promega-technology-enabled custom solution: Faster time to data; Fewer in-house resources; Flexible approach and offerings.

cAMP-Glo™ Assay

The cAMP-Glo™ Assay is a bioluminescence assay for monitoring changes in intracellular cAMP concentration with high sensitivity and excellent reproducibility. The assay is robust, easy to use and can be formatted to any size of experiment from single tubes to high-density plates.

Protein Kinases

We offer several protein kinases and kinase catalytic subunits including PKA, PKC, DNA- PK, Casein Kinase I and II, the EGF receptor and cGMP-dependent PK.

Featured Resources

pubhub_fr Monitoring the Activity of GPCR Modulated by Lipid or Free Fatty Acid Agonists

In this article we present data extending the application of the cAMP-Glo™ Assay using receptors that are modulated by lipid and free fatty acid agonists.

PAG_CellSignaling_fr Cell Signaling

This chapter of the Protocols and Applications Guide describes the molecular basis of cell signaling and the various assays used to study cell signaling.

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Scientists at Your Service

Scientists at Your Service

We offer a range of services to help you succeed using Promega technologies. From product training to set up of automated systems and development of custom applications—our scientific support goes beyond the basics.

Ask us! We are here to help you.