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Promega Corporation

TOPK Kinase Enzyme System

See All Kinase Enzyme Systems
Recombinant full-length human TOPK was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. TOPK is a MAPK kinase that phosphorylates p38 MAPK and is activated in a cell-cycle-dependent manner in neuronal progenitor cells in vitro (1). Expression of TOPK is detected in male germ line progenitor cells, activated T-cells and a variety of lymphomas and leukemias. In vitro studies have shown that activated TOPK phosphorylates p38 MAPK but not JNK or ERK. TOPK activation requires phosphorylation by both the M-phase CDK1/CyclinB kinase complex and another unknown kin...

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Product Size Conc. Catalog # *List Price Order QTY Add to Cart
TOPK Kinase Enzyme System
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TOPK Kinase Enzyme System  Components

10μg
- V4094 $ 406.00 Add to cart

TOPK Kinase Enzyme System

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TOPK Kinase Enzyme System

 Components

1mg
- V6568 $ 5,990.00 Add to cart
ADP-Glo™ Kinase Assay + TOPK Kinase Enzyme System
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ADP-Glo™ Kinase Assay + TOPK Kinase Enzyme System  Components

  • TOPK Kinase Enzyme System

    V40941 x 10μg
  • ADP-Glo™ Kinase Assay

    V91011 x 1,000 assays
1 each
- V4095 $ 808.00 Add to cart


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Storage Conditions

Upon receipt, centrifuge the kinase and dispense it into smaller quantities. Store the kinase at –70°C and the rest of the components at –20°C.

For product intended use please see Patents & Disclaimers tab.

Use Restrictions

V4094, V6568, V4095 For Research Use Only. Not for Use in Diagnostic Procedures.

Patents - Disclaimers

V4095 U.S. Pat. Nos. 7,083,911, 7,452,663 and 7,732,128 and other patents.

V4095 U.S. Pat. No. 7,700,310 and other patents and patents pending.

V4095 U.S. Pat. Nos. 7,741,067, 8,361,739, 8,603,767 and other patents and patents pending.

V4095 U.S. Pat. Nos. 6,602,677, 7,241,584 and 8,030,017 and other patents and patents pending.

V4095 U.S. Pat. No. 8,183,007 and other patents and patents pending.

V4095 Licensed from Lonza Nottingham Ltd. under U.S. Pat. Nos. 6,599,711 and 6,911,319 and other pending and issued patents.

V4095 The method of recombinant expression of Coleoptera luciferase is covered by U.S. Pat. Nos. 5,583,024, 5,674,713 and 5,700,673.

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