POLR2B, RNA polymerase II subunit B

POLR2B, RNA polymerase II subunit B

• This gene encodes the second largest subunit of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase that catalyzes the transcription of DNA into precursors of mRNA, snRNA and microRNA. This subunit and the largest subunit form opposite sides of the center cleft of Pol II. Deletion of the flap loop region of this subunit results in a decrease in the rate of transcriptional elongation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

• Gene Synonyms (DNA-directed RNA polymerase II subunit RPB2, DNA-directed RNA polymerase II 140 kDa polypeptide, DNA-directed RNA polymerase II subunit B, RNA polymerase II second largest subunit, RNA polymerase II subunit 2, RNA polymerase II subunit B2, polymerase (RNA) II (DNA directed) polypeptide B, 140kDa, polymerase (RNA) II subunit B, POL2RB, RPB2, hRPB140,)
• NCBI Gene ID: 5431
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P30876
  UNIPROT ID#>>B4DH29
  UNIPROT ID#>>C9J2Y9
  UNIPROT ID#>>A0A1W2PPT5
  UNIPROT ID#>>B4DHJ3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

RNA polymerase II subunit B interacts with:

• 5'-3' exoribonuclease 2
  AAR2 splicing factor
  ankyrin repeat and SOCS box containing 6
  autophagy related 16 like 1
  BCL2 like 14
  BCL2-associated athanogene 2
  bromodomain containing 2
  copine 2
  CTD phosphatase subunit 1
  CTR9 homolog, Paf1/RNA polymerase II complex component
  cullin 3
  cullin 5
  cullin associated and neddylation dissociated 1
  cyclin dependent kinase 20
  DnaJ heat shock protein family (Hsp40) member C7
  dynactin subunit 4
  egl-9 family hypoxia inducible factor 3
  elongin A
  eukaryotic elongation factor, selenocysteine-tRNA specific
  exportin 1
  F-box protein 6
  G3BP stress granule assembly factor 1
  general transcription factor IIB
  glutamate rich WD repeat containing 1
  GPN-loop GTPase 1
  GPN-loop GTPase 2
  GPN-loop GTPase 3
  H4 clustered histone 1
  HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
  histone deacetylase 11
  hypoxia inducible factor 1 subunit alpha inhibitor
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  INO80 complex subunit B
  integrator complex subunit 1
  integrator complex subunit 10
  integrator complex subunit 3
  integrator complex subunit 5
  integrator complex subunit 6
  integrin alpha FG-GAP repeat containing 1
  itchy E3 ubiquitin protein ligase
  leucine zipper like transcription regulator 1
  limb development membrane protein 1 like
  lysine demethylase 1A
  macroH2A.1 histone
  mediator complex subunit 10
  mediator complex subunit 19
  mediator complex subunit 26
  mediator complex subunit 28
  mediator complex subunit 29
  mediator complex subunit 4
  mediator complex subunit 9
  mediator of DNA damage checkpoint 1
  MINDY lysine 48 deubiquitinase 4
  mitogen-activated protein kinase 6
  mitogen-activated protein kinase kinase kinase 14
  negative elongation factor complex member A
  nuclear receptor subfamily 2 group C member 2
  obscurin like cytoskeletal adaptor 1
  OTU deubiquitinase 5
  p53-induced death domain protein 1
  pelota mRNA surveillance and ribosome rescue factor
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  proteasome 20S subunit beta 9
  protein phosphatase 1 catalytic subunit gamma
  rabaptin, RAB GTPase binding effector protein 2
  receptor interacting serine/threonine kinase 4
  RecQ like helicase 4
  RecQ like helicase 5
  regulation of nuclear pre-mRNA domain containing 1B
  regulation of nuclear pre-mRNA domain containing 1B
  required for meiotic nuclear division 5 homolog A
  ribosomal protein L35
  ribosomal protein S5
  ring finger protein 2
  ring-box 1
  RNA guanylyltransferase and 5'-phosphatase
  RNA polymerase I subunit A
  RNA polymerase I subunit B
  RNA polymerase II associated protein 1
  RNA polymerase II associated protein 2
  RNA polymerase II associated protein 3
  RNA polymerase II subunit B
  RNA polymerase II subunit C
  RNA polymerase II subunit D
  RNA polymerase II subunit G
  RNA polymerase II subunit I
  RNA polymerase II subunit J
  RNA polymerase II subunit M
  RNA polymerase II, I and III subunit E
  RNA polymerase II, I and III subunit F
  RNA polymerase II, I and III subunit H
  RNA polymerase II, I and III subunit K
  RNA polymerase II, I and III subunit L
  RNA polymerase III subunit A
  RNA polymerase III subunit F
  RuvB like AAA ATPase 1
  RuvB like AAA ATPase 2
  RuvB-like protein 1
  SEM1 26S proteasome complex subunit
  snail family transcriptional repressor 1
  spindle apparatus coiled-coil protein 1
  SPT5 homolog, DSIF elongation factor subunit
  SRC proto-oncogene, non-receptor tyrosine kinase
  staufen double-stranded RNA binding protein 1
  SUB1 regulator of transcription
  suppressor of cancer cell invasion
  SUZ12 polycomb repressive complex 2 subunit
  TNFAIP3 interacting protein 2
  transcription elongation factor A1
  transcriptional adaptor 2A
  treacle ribosome biogenesis factor 1
  tripartite motif containing 25
  tripartite motif containing 28
  tubulin alpha 4a
  tubulin beta 4B class IVb
  tubulin beta class I
  unc-93 homolog B1, TLR signaling regulator
  URI1 prefoldin like chaperone
  valosin containing protein
  vir like m6A methyltransferase associated
  WD repeat domain 82
  WD repeat domain 92
  WW domain containing E3 ubiquitin protein ligase 2
  WW domain containing oxidoreductase
  zinc finger and SCAN domain containing 1
  zinc finger CCCH-type containing 13
  zinc finger containing ubiquitin peptidase 1
  zinc finger MYND-type containing 8

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.