TOPBP1, DNA topoisomerase II binding protein 1

TOPBP1, DNA topoisomerase II binding protein 1

• This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands. [provided by RefSeq, Jul 2008]

• Gene Synonyms (DNA topoisomerase 2-binding protein 1, DNA topoisomerase II-beta-binding protein 1, topoisomerase (DNA) II binding protein 1, Dpb11, TOP2BP1,)
• NCBI Gene ID: 11073
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0AV47
  UNIPROT ID#>>Q05BV8
  UNIPROT ID#>>Q92547
  UNIPROT ID#>>A7E2X7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

DNA topoisomerase II binding protein 1 interacts with:

• ATR interacting protein
  BRCA1 interacting protein C-terminal helicase 1
  calsyntenin 1
  cerebellin 4 precursor
  D-aminoacyl-tRNA deacylase 1
  DNA topoisomerase II binding protein 1
  egl-9 family hypoxia inducible factor 3
  HUS1 checkpoint clamp component
  MDM2 binding protein
  microcephalin 1
  periphilin 1
  peroxisome proliferator activated receptor gamma
  pleckstrin homology domain containing A4
  polo like kinase 1
  RAD9-HUS1-RAD1 interacting nuclear orphan 1
  RecQ mediated genome instability 1
  ribosome binding protein 1
  RNA polymerase II associated protein 2
  sirtuin 1
  SLX4 structure-specific endonuclease subunit
  SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
  testis expressed 11
  TOPBP1 interacting checkpoint and replication regulator
  ubiquitin protein ligase E3 component n-recognin 5
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.