ARHGAP11A, Rho GTPase activating protein 11A

ARHGAP11A, Rho GTPase activating protein 11A

• This gene encodes a member of the Rho GTPase activating protein family. In response to DNA damage, the encoded protein interacts with the p53 tumor suppressor protein and stimulates its tetramerization, which results in cell-cycle arrest and apoptosis. A chromosomal deletion that includes this gene is one cause of Prader-Willi syndrome, and an intronic variant of this gene may be associated with sleep duration in children. This gene is highly expressed in colon cancers and in a human basal-like breast cancer cell line. This gene also produces a ARHGAP11A-SCG5 readthrough transcript and ARHGAP11A-SCG5 protein. [provided by RefSeq, Feb 2019]

• Gene Synonyms (rho GTPase-activating protein 11A, rho-type GTPase-activating protein 11A, GAP (1-12),)
• NCBI Gene ID: 9824
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q6P4F7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Rho GTPase activating protein 11A interacts with:

• actin, beta
  anillin actin binding protein
  calmodulin-like 3
  coronin, actin binding protein 1C
  F-box protein 38
  flotillin 2
  kinesin family member 5B
  myosin IC
  myosin VC
  myosin XIX
  myosin XVIIIA
  myosin, heavy polypeptide 10, non-muscle
  myosin, heavy polypeptide 9, non-muscle
  nuclear RNA export factor 1
  ring finger protein 123
  synaptopodin
  transmembrane p24 trafficking protein 10
  tropomyosin 1, alpha
  vacuolar protein sorting 4B
  vacuole membrane protein 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.