CLCA2, chloride channel accessory 2

CLCA2, chloride channel accessory 2

• This gene encodes a member of the calcium-activated chloride channel regulator (CLCR) family of proteins. Members of this family regulate the transport of chloride across the plasma membrane. The encoded protein is autoproteolytically processed to generate N- and C- terminal fragments. Expression of this gene is upregulated by the tumor suppressor protein p53 in response to DNA damage. In breast cancer, expression of this gene is downregulated and the encoded protein may inhibit migration and invasion while promoting mesenchymal-to-epithelial transition in cancer cell lines. [provided by RefSeq, Sep 2016]

• Gene Synonyms (calcium-activated chloride channel regulator 2, CLCA family member 2, chloride channel regulator, calcium-activated chloride channel protein 3, chloride channel, calcium activated, family member 2, CACC, CACC3, CLCRG2, CaCC-3,)
• NCBI Gene ID: 9635
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UQC9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

chloride channel accessory 2 interacts with:

• NDC1 transmembrane nucleoporin

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.