EI24, EI24 autophagy associated transmembrane protein

EI24, EI24 autophagy associated transmembrane protein

• This gene encodes a putative tumor suppressor and has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The encoded protein may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, 7, and 8. [provided by RefSeq, Feb 2014]

• Gene Synonyms (etoposide-induced protein 2.4 homolog, ectopic P-granules autophagy protein 4 homolog, etoposide induced 2.4, p53-induced gene 8 protein, tumor protein p53 inducible protein 8, EPG4, PIG8, TP53I8,)
• NCBI Gene ID: 9538
• Species: Homo sapiens (Human)
• UNIPROT ID#>>E9PK61
  UNIPROT ID#>>A0A024R3I8
  UNIPROT ID#>>O14681
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

EI24 autophagy associated transmembrane protein interacts with:

• OTU deubiquitinase with linear linkage specificity like
  pleckstrin homology domain containing A4
  progesterone receptor membrane component 2
  Rab acceptor 1
  solute carrier family 15 member 3
  tectonic family member 3
  tetratricopeptide repeat domain 30B
  transmembrane p24 trafficking protein family member 8
  transmembrane protein 14B
  unc-93 homolog B1, TLR signaling regulator

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.