NAPSA, napsin A aspartic peptidase

NAPSA, napsin A aspartic peptidase

• This gene encodes a member of the peptidase A1 family of aspartic proteases. The encoded preproprotein is proteolytically processed to generate an activation peptide and the mature protease. The activation peptides of aspartic proteinases function as inhibitors of the protease active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The encoded protease may play a role in the proteolytic processing of pulmonary surfactant protein B in the lung and may function in protein catabolism in the renal proximal tubules. This gene has been described as a marker for lung adenocarcinoma and renal cell carcinoma. [provided by RefSeq, Feb 2016]

• Gene Synonyms (napsin-A, ASP4, TA01/TA02, asp 4, aspartyl protease 4, kidney-derived aspartic protease-like protein, napsin-1, pronapsin A, KAP, Kdap, NAP1, NAPA, SNAPA,)
• NCBI Gene ID: 9476
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O96009
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

napsin A aspartic peptidase interacts with:

• ADAM metallopeptidase with thrombospondin type 1 motif 1
  late cornified envelope 1B
  retinol dehydrogenase 13

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.