CYP7B1, cytochrome P450 family 7 subfamily B member 1

CYP7B1, cytochrome P450 family 7 subfamily B member 1

• This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway of extrahepatic tissues, which converts cholesterol to bile acids. This enzyme likely plays a minor role in total bile acid synthesis, but may also be involved in the development of atherosclerosis, neurosteroid metabolism and sex hormone synthesis. Mutations in this gene have been associated with hereditary spastic paraplegia (SPG5 or HSP), an autosomal recessive disorder. [provided by RefSeq, Apr 2016]

• Gene Synonyms (cytochrome P450 7B1, 24-hydroxycholesterol 7-alpha-hydroxylase, 25-hydroxycholesterol 7-alpha-hydroxylase, 25/26-hydroxycholesterol 7-alpha-hydroxylase, 3-hydroxysteroid 7-alpha hydroxylase, cytochrome P450, subfamily VIIB (oxysterol 7 alpha-hydroxylase), polypeptide 1, oxysterol 7-alpha-hydroxylase, CBAS3, CP7B, SPG5A,)
• NCBI Gene ID: 9420
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q05C57
  UNIPROT ID#>>O75881
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

cytochrome P450 family 7 subfamily B member 1 interacts with:

• growth hormone inducible transmembrane protein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.