PGAP3, post-GPI attachment to proteins phospholipase 3

PGAP3, post-GPI attachment to proteins phospholipase 3

• This gene encodes a glycosylphosphatidylinositol (GPI)-specific phospholipase that primarily localizes to the Golgi apparatus. This ubiquitously expressed gene is predicted to encode a seven-transmembrane protein that removes unsaturated fatty acids from the sn-2 position of GPI. The remodeling of the constituent fatty acids on GPI is thought to be important for the proper association between GPI-anchored proteins and lipid rafts. The tethering of proteins to plasma membranes via posttranslational GPI-anchoring is thought to play a role in protein sorting and trafficking. Mutations in this gene cause an autosomal recessive form of neurologic hyperphosphatasia with cognitive disability (HPMRS4). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017]

• Gene Synonyms (post-GPI attachment to proteins factor 3, COS16 homolog, gene coamplified with ERBB2 protein, per1-like domain containing 1, post-GPI attachment to proteins 3, AGLA546, CAB2, PERLD1, PP1498, hCOS16,)
• NCBI Gene ID: 93210
• Species: Homo sapiens (Human)
• UNIPROT ID#>>J3QKU0
  UNIPROT ID#>>Q96FM1
  UNIPROT ID#>>A8K0P7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

post-GPI attachment to proteins phospholipase 3 interacts with:

• vitamin K epoxide reductase complex subunit 1 like 1

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