GCM2, glial cells missing transcription factor 2

GCM2, glial cells missing transcription factor 2

• This gene is a homolog of the Drosophila glial cells missing gene, which is thought to act as a binary switch between neuronal and glial cell determination. The protein encoded by this gene contains a conserved N-terminal GCM motif that has DNA-binding activity. The protein is a transcription factor that acts as a master regulator of parathyroid development. It has been suggested that this transcription factor might mediate the effect of calcium on parathyroid hormone expression and secretion in parathyroid cells. Mutations in this gene are associated with hypoparathyroidism. [provided by RefSeq, Jul 2008]

• Gene Synonyms (chorion-specific transcription factor GCMb, GCM motif protein 2, glial cells missing 2, glial cells missing homolog 2, glial cells missing homolog b, glide/gcm protein homolog, FIH2, GCMB, HRPT4, hGCMb,)
• NCBI Gene ID: 9247
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O75603
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

glial cells missing transcription factor 2 interacts with:

• docking protein 3
  G protein signaling modulator 1
  heat shock transcription factor 2 binding protein
  heat shock transcription factor Y-linked 1
  heat shock transcription factor Y-linked 2
  jumonji domain containing 7
  keratin associated protein 6-2
  keratin associated protein 7-1
  keratin associated protein 8-1
  myozenin 3
  pleckstrin homology and RhoGEF domain containing G4
  POU class 6 homeobox 2
  RNA binding protein, mRNA processing factor
  RUN and SH3 domain containing 1
  TOX high mobility group box family member 3
  ubiquitin specific peptidase 54
  WW domain containing oxidoreductase
  yippee like 3
  zinc finger MIZ-type containing 2
  zinc finger protein 34

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.