AKR1C3, aldo-keto reductase family 1 member C3

AKR1C3, aldo-keto reductase family 1 member C3

• This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

• Gene Synonyms (aldo-keto reductase family 1 member C3, 3-alpha hydroxysteroid dehydrogenase, type II, 3-alpha-HSD type II, brain, chlordecone reductase homolog HAKRb, dihydrodiol dehydrogenase 3, dihydrodiol dehydrogenase X, indanol dehydrogenase, prostaglandin F synthase, testosterone 17-beta-dehydrogenase 5, trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, type IIb 3-alpha hydroxysteroid dehydrogenase, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS,)
• NCBI Gene ID: 8644
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A0A0MSS8
  UNIPROT ID#>>B4DKT3
  UNIPROT ID#>>P42330
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

aldo-keto reductase family 1 member C3 interacts with:

• anterior gradient 2, protein disulphide isomerase family member
  apoptotic chromatin condensation inducer 1
  ligand dependent nuclear receptor interacting factor 1
  ubiquitin conjugating enzyme E2 W
  zinc fingers and homeoboxes 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.