PDE8B, phosphodiesterase 8B

PDE8B, phosphodiesterase 8B

• The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]

• Gene Synonyms (high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B, 3',5' cyclic nucleotide phosphodiesterase 8B, cell proliferation-inducing gene 22 protein, ADSD, PPNAD3,)
• NCBI Gene ID: 8622
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O95263
  UNIPROT ID#>>B3KN77
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

phosphodiesterase 8B interacts with:

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.