PDZD3, PDZ domain containing 3

PDZD3, PDZ domain containing 3

• Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]).[supplied by OMIM, Mar 2008]

• Gene Synonyms (Na(+)/H(+) exchange regulatory cofactor NHE-RF4, NHERF-4, PDZ domain containing 2, PDZ domain-containing protein 2, PDZ domain-containing protein 3, intestinal and kidney enriched PDZ protein, na/Pi cotransporter C-terminal-associated protein 2, naPi-Cap2, natrium-phosphate cotransporter IIa C-terminal-associated protein 2, sodium-hydrogen exchanger regulatory factor 4, IKEPP, NHERF4, PDZK2,)
• NCBI Gene ID: 79849
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B0YJ61
  UNIPROT ID#>>Q86UT5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

PDZ domain containing 3 interacts with:

• solute carrier family 22 member 9

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.