DYNC2H1, dynein cytoplasmic 2 heavy chain 1

DYNC2H1, dynein cytoplasmic 2 heavy chain 1

• This gene encodes a large cytoplasmic dynein protein that is involved in retrograde transport in the cilium and has a role in intraflagellar transport, a process required for ciliary/flagellar assembly. Mutations in this gene cause a heterogeneous spectrum of conditions related to altered primary cilium function and often involve polydactyly, abnormal skeletogenesis, and polycystic kidneys. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jan 2010]

• Gene Synonyms (cytoplasmic dynein 2 heavy chain 1, dynein cytoplasmic heavy chain 2, dynein heavy chain 11, dynein heavy chain, isotype 1B, dynein, cytoplasmic, heavy polypeptide 2, ATD3, DHC1b, DHC2, DNCH2, DYH1B, SRPS2B, SRTD3, hdhc11,)
• NCBI Gene ID: 79659
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8NCM8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

dynein cytoplasmic 2 heavy chain 1 interacts with:

• Cobl-like 1
  major facilitator superfamily domain containing 4B
  SPC24 component of NDC80 kinetochore complex
  tigger transposable element derived 6
  tubulin, gamma 1
  ubiquitin specific peptidase 50
  VANGL planar cell polarity 1
  WD repeat domain 5

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.