SECISBP2, SECIS binding protein 2

SECISBP2, SECIS binding protein 2

• The protein encoded by this gene is one of the essential components of the machinery involved in co-translational insertion of selenocysteine (Sec) into selenoproteins. Sec is encoded by the UGA codon, which normally signals translation termination. The recoding of UGA as Sec codon requires a Sec insertion sequence (SECIS) element; present in the 3' untranslated regions of eukaryotic selenoprotein mRNAs. This protein specifically binds to the SECIS element, which is stimulated by a Sec-specific translation elongation factor. Mutations in this gene have been associated with reduction in enzymatic activity of type II iodothyronine deiodinase (a selenoprotein) and abnormal thyroid hormone metabolism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017]

• Gene Synonyms (selenocysteine insertion sequence-binding protein 2, Sec insertion sequence-binding protein 2, SBP2,)
• NCBI Gene ID: 79048
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q96T21
  UNIPROT ID#>>B4DR97
  UNIPROT ID#>>B4DZC7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

SECIS binding protein 2 interacts with:

• egl-9 family hypoxia inducible factor 3
  spindle and centriole associated protein 1

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