UNG, uracil DNA glycosylase

UNG, uracil DNA glycosylase

• This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq, Nov 2010]

• Gene Synonyms (uracil-DNA glycosylase, uracil-DNA glycosylase 1, uracil-DNA glycosylase 2, DGU, HIGM4, HIGM5, UDG, UNG1, UNG15, UNG2,)
• NCBI Gene ID: 7374
• Species: Homo sapiens (Human)
• UNIPROT ID#>>E5KTA5
  UNIPROT ID#>>P13051
  UNIPROT ID#>>E5KTA6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

uracil DNA glycosylase interacts with:

• calpain 11
  DDB1 and CUL4 associated factor 1
  H2B clustered histone 8
  H3 clustered histone 1
  protein phosphatase 2 regulatory subunit Bdelta
  protein phosphatase 2, regulatory subunit B, delta
  protein phosphatase, Mg2+/Mn2+ dependent 1D
  seizure related 6 homolog like 2
  single-strand-selective monofunctional uracil-DNA glycosylase 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.