- Gene Overview
- Interaction Network
- Sequence Verification
CCR2, C-C motif chemokine receptor 2
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The protein encoded by this gene is a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The encoded protein mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This protein can also be a coreceptor with CD4 for HIV-1 infection. This gene is located in the chemokine receptor gene cluster region of chromosome 3. [provided by RefSeq, Aug 2017]
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Gene Synonyms (CC-CKR-2, CCR-2, CCR2A, CCR2B, CD192, CKR2, CKR2A, CKR2B, CMKBR2, MCP-1-R, C-C chemokine receptor type 2, MCP-1 receptor, chemokine (C-C motif) receptor 2, monocyte chemoattractant protein 1 receptor, monocyte chemotactic protein 1 receptor,)
- NCBI Gene ID:
729230
- Species:
Homo sapiens (Human)
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UNIPROT ID#>>A0A024R2Q0
UNIPROT ID#>>P41597
- View the NCBI Database
for this Gene »
Gene products are often involved in multiple pathways and networks within a living
cell. Learn more about other interacting partners.
C-C motif chemokine receptor 2 interacts with:
Paste a protein or nucleic acid sequence in the box below to confirm that it matches
this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see
how a sequence matches to an experimentally-validated ORF clone.
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