TFAP2B, transcription factor AP-2 beta

TFAP2B, transcription factor AP-2 beta

• This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives. [provided by RefSeq, Jul 2008]

• Gene Synonyms (transcription factor AP-2-beta, AP2-beta, activating enhancer binding protein 2 beta, AP-2B, AP2-B, PDA2,)
• NCBI Gene ID: 7021
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q92481
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

transcription factor AP-2 beta interacts with:

• Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2
  Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4
  H2A clustered histone 6
  leucine zipper like transcription regulator 1
  potassium channel tetramerization domain containing 1
  single stranded DNA binding protein 4
  tumor protein p53
  ubiquitin conjugating enzyme E2 I
  VPS11 core subunit of CORVET and HOPS complexes
  YEATS domain containing 4

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.