SOD3, superoxide dismutase 3

SOD3, superoxide dismutase 3

• This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the conversion of superoxide radicals into hydrogen peroxide and oxygen, which may protect the brain, lungs, and other tissues from oxidative stress. Proteolytic processing of the encoded protein results in the formation of two distinct homotetramers that differ in their ability to interact with the extracellular matrix (ECM). Homotetramers consisting of the intact protein, or type C subunit, exhibit high affinity for heparin and are anchored to the ECM. Homotetramers consisting of a proteolytically cleaved form of the protein, or type A subunit, exhibit low affinity for heparin and do not interact with the ECM. A mutation in this gene may be associated with increased heart disease risk. [provided by RefSeq, Oct 2015]

• Gene Synonyms (extracellular superoxide dismutase [Cu-Zn], superoxide dismutase 3, extracellular, testicular tissue protein Li 175, EC-SOD,)
• NCBI Gene ID: 6649
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A140VJU8
  UNIPROT ID#>>P08294
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

superoxide dismutase 3 interacts with:

• fibulin 5
  golgi membrane protein 2
  potassium voltage-gated channel interacting protein 1
  potassium voltage-gated channel interacting protein 3
  sequestosome 1
  small glutamine rich tetratricopeptide repeat containing beta
  ubiquilin 1
  ubiquilin 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.