SLC10A2, solute carrier family 10 member 2

SLC10A2, solute carrier family 10 member 2

• This gene encodes a sodium/bile acid cotransporter. This transporter is the primary mechanism for uptake of intestinal bile acids by apical cells in the distal ileum. Bile acids are the catabolic product of cholesterol metabolism, so this protein is also critical for cholesterol homeostasis. Mutations in this gene cause primary bile acid malabsorption (PBAM); muatations in this gene may also be associated with other diseases of the liver and intestines, such as familial hypertriglyceridemia (FHTG). [provided by RefSeq, Mar 2010]

• Gene Synonyms (ileal sodium/bile acid cotransporter, Na(+)-dependent ileal bile acid transporter, ileal apical sodium-dependent bile acid transporter, ileal sodium-dependent bile acid transporter, sodium/taurocholate cotransporting polypeptide, ileal, solute carrier family 10 (sodium/bile acid cotransporter family), member 2, solute carrier family 10 (sodium/bile acid cotransporter), member 2, ASBT, IBAT, ISBT, NTCP2, PBAM,)
• NCBI Gene ID: 6555
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q12908
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

solute carrier family 10 member 2 interacts with:

• C-C motif chemokine ligand 4 like 2
  chromosome 3 open reading frame 52
  cortexin 3
  interferon induced transmembrane protein 3
  nurim
  peptidylprolyl isomerase E
  presenilin enhancer, gamma-secretase subunit
  testis expressed 264, ER-phagy receptor
  transmembrane protein 222
  uroplakin 1B

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.