- Gene Overview
- Interaction Network
- Sequence Verification
GREM2, gremlin 2, DAN family BMP antagonist
-
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. [provided by RefSeq, Jul 2008]
-
Gene Synonyms (gremlin-2, DAN domain family member 3, cysteine knot superfamily 1, BMP antagonist 2, gremlin 2, cysteine knot superfamily, homolog, protein related to DAN and cerberus, CKTSF1B2, DAND3, PRDC, STHAG9,)
- NCBI Gene ID:
64388
- Species:
Homo sapiens (Human)
-
UNIPROT ID#>>Q9H772
UNIPROT ID#>>A0A024R3Y1
- View the NCBI Database
for this Gene »
Gene products are often involved in multiple pathways and networks within a living
cell. Learn more about other interacting partners.
gremlin 2, DAN family BMP antagonist interacts with:
Paste a protein or nucleic acid sequence in the box below to confirm that it matches
this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see
how a sequence matches to an experimentally-validated ORF clone.
|