CLSPN, claspin

CLSPN, claspin

• The product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. The protein is also required for efficient DNA replication during a normal S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

• Gene Synonyms (claspin, claspin homolog,)
• NCBI Gene ID: 63967
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9HAW4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

claspin interacts with:

• egl-9 family hypoxia inducible factor 3
  F-box protein 38
  GINS complex subunit 3
  MAD2L1 binding protein
  primase and DNA directed polymerase
  timeless interacting protein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.