SPTBN4, spectrin beta, non-erythrocytic 4

SPTBN4, spectrin beta, non-erythrocytic 4

• Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein localizes to the nuclear matrix, PML nuclear bodies, and cytoplasmic vesicles. A highly similar gene in the mouse is required for localization of specific membrane proteins in polarized regions of neurons. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (CMND, NEDHND, QV, SPNB4, SPTBN3, spectrin beta chain, non-erythrocytic 4, beta-IV spectrin, spectrin beta chain, brain 3, spectrin, non-erythroid beta chain 3,)
• NCBI Gene ID: 57731
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9H254
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

spectrin beta, non-erythrocytic 4 interacts with:

• centromere protein U
  NHL repeat containing 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.