ARNTL2, aryl hydrocarbon receptor nuclear translocator like 2

ARNTL2, aryl hydrocarbon receptor nuclear translocator like 2

• This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

• Gene Synonyms (BMAL2, CLIF, MOP9, PASD9, bHLHe6, aryl hydrocarbon receptor nuclear translocator-like protein 2, CYCLE-like factor, PAS domain-containing protein 9, basic-helix-loop-helix-PAS protein MOP9, brain and muscle ARNT-like 2, class E basic helix-loop-helix protein 6, member of PAS protein 9, transcription factor BMAL2,)
• NCBI Gene ID: 56938
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8WYA1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

aryl hydrocarbon receptor nuclear translocator like 2 interacts with:

• CLOCK interacting pacemaker
  cortactin binding protein 2
  FRAS1 related extracellular matrix 2
  HAUS augmin like complex subunit 1
  NOP9 nucleolar protein
  zinc finger BED-type containing 8

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.