SPPL2B, signal peptide peptidase like 2B

SPPL2B, signal peptide peptidase like 2B

• This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (IMP-4, IMP4, PSH4, PSL1, signal peptide peptidase-like 2B, SPP-like 2B, intramembrane protease 4, presenilin homologous protein 4, presenilin-like protein 1,)
• NCBI Gene ID: 56928
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8TCT7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

signal peptide peptidase like 2B interacts with:

• 3-hydroxyacyl-CoA dehydratase 2
  5-hydroxytryptamine receptor 3C
  adhesion G protein-coupled receptor G5
  ALG10 alpha-1,2-glucosyltransferase
  BRI3 binding protein
  CD300e molecule
  centrosomal protein 44
  choline phosphotransferase 1
  CKLF like MARVEL transmembrane domain containing 4
  cyclin Y like 1
  ectonucleoside triphosphate diphosphohydrolase 7
  family with sequence similarity 187 member B
  fat storage inducing transmembrane protein 2
  golgi membrane protein 2
  magnesium transporter MRS2
  major facilitator superfamily domain containing 5
  metallophosphoesterase 1
  mitochondrial antiviral signaling protein
  oxysterol binding protein like 8
  phosphatidylinositol glycan anchor biosynthesis class U
  phosphatidylinositol glycan anchor biosynthesis class W
  phospholipase D family member 6
  post-glycosylphosphatidylinositol attachment to proteins 6
  serine incorporator 1
  signal peptide peptidase like 3
  solute carrier family 30 member 5
  solute carrier family 35 member B2
  solute carrier family 35 member G2
  solute carrier family 52 member 2
  spectrin repeat containing nuclear envelope family member 4
  thioredoxin domain containing 15
  TLC domain containing 1
  trans-golgi network vesicle protein 23 homolog C
  transmembrane p24 trafficking protein 4
  transmembrane protein 43
  ubiquitin specific peptidase 28
  Yip1 domain family member 4
  Yip1 domain family member 6

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.