SULF2, sulfatase 2

SULF2, sulfatase 2

• Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008]

• Gene Synonyms (HSULF-2, extracellular sulfatase Sulf-2,)
• NCBI Gene ID: 55959
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8IWU5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

sulfatase 2 interacts with:

• G protein-coupled receptor 156
  kelch repeat and BTB domain containing 7
  leucine rich repeat containing 4C
  TNFAIP3 interacting protein 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.