PNPO, pyridoxamine 5'-phosphate oxidase

PNPO, pyridoxamine 5'-phosphate oxidase

• The enzyme encoded by this gene catalyzes the terminal, rate-limiting step in the synthesis of pyridoxal 5'-phosphate, also known as vitamin B6. Vitamin B6 is a required co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine. Mutations in this gene result in pyridoxamine 5'-phosphate oxidase (PNPO) deficiency, a form of neonatal epileptic encephalopathy. [provided by RefSeq, Oct 2008]

• Gene Synonyms (pyridoxine-5'-phosphate oxidase, epididymis secretory protein Li 302, epididymis secretory sperm binding protein, pyridoxal 5'-phosphate synthase, pyridoxamine-phosphate oxidase, pyridoxine 5'-phosphate oxidase, HEL-S-302, PDXPO,)
• NCBI Gene ID: 55163
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9NVS9
  UNIPROT ID#>>V9HW45
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

pyridoxamine 5'-phosphate oxidase interacts with:

• ADP ribosylation factor like GTPase 6 interacting protein 6
  angiotensin II receptor associated protein
  CKLF like MARVEL transmembrane domain containing 5
  solute carrier family 25 member 32
  transport and golgi organization 2 homolog

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.