DUS2, dihydrouridine synthase 2

DUS2, dihydrouridine synthase 2

• This gene encodes a cytoplasmic protein that catalyzes the conversion of uridine residues to dihydrouridine in the D-loop of tRNA. The resulting modified bases confer enhanced regional flexibility to tRNA. The encoded protein may increase the rate of translation by inhibiting an interferon-induced protein kinase. This gene has been implicated in pulmonary carcinogenesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]

• Gene Synonyms (tRNA-dihydrouridine(20) synthase [NAD(P)+]-like, SMM1 homolog, dihydrouridine synthase 2-like, SMM1 homolog, tRNA-dihydrouridine(20) synthase (NAD(P)(+)), up-regulated in lung cancer protein 8, DUS2L, SMM1, URLC8,)
• NCBI Gene ID: 54920
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R6Z7
  UNIPROT ID#>>B4DKP8
  UNIPROT ID#>>E7EUN9
  UNIPROT ID#>>Q9NX74
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

dihydrouridine synthase 2 interacts with:

• KAT8 regulatory NSL complex subunit 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.