UGT1A4, UDP glucuronosyltransferase family 1 member A4

UGT1A4, UDP glucuronosyltransferase family 1 member A4

• This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. This enzyme has some glucuronidase activity towards bilirubin, although is is more active on amines, steroids, and sapogenins. [provided by RefSeq, Jul 2008]

• Gene Synonyms (UDP-glucuronosyltransferase 1A4, Bilirubin-specific UDPGT isozyme 1, UDP glucuronosyltransferase 1 family, polypeptide A4, UDP glycosyltransferase 1 family, polypeptide A4, UDP-glucuronosyltransferase 1 family polypeptide A4s, UDP-glucuronosyltransferase 1-1, UDP-glucuronosyltransferase 1-4, UDP-glucuronosyltransferase 1-A, UDP-glucuronosyltransferase 1-D, UDP-glucuronosyltransferase 1A1, UDPGT 1-1, bilirubin UDP-glucuronosyltransferase isozyme 2, bilirubin-specific UDPGT isozyme 2, GNT1, HUG-BR2, UDPGT, UDPGT 1-4, UGT-1A, UGT-1D, UGT1, UGT1-01, UGT1-04, UGT1.1, UGT1.4, UGT1A, UGT1A1, UGT1A4S, UGT1D, hUG-BR1,)
• NCBI Gene ID: 54657
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P22310
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

UDP glucuronosyltransferase family 1 member A4 interacts with:

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