GSKIP, GSK3B interacting protein

GSKIP, GSK3B interacting protein

• This gene encodes a protein that is involved as a negative regulator of GSK3-beta in the Wnt signaling pathway. The encoded protein may play a role in the retinoic acid signaling pathway by regulating the functional interactions between GSK3-beta, beta-catenin and cyclin D1, and it regulates the beta-catenin/N-cadherin pool. The encoded protein contains a GSK3-beta interacting domain (GID) in its C-terminus, which is similar to the GID of Axin. The protein also contains an evolutionarily conserved RII-binding domain, which facilitates binding with protein kinase-A and GSK3-beta, enabling its role as an A-kinase anchoring protein. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]

• Gene Synonyms (GSK3B-interacting protein, GSK3-beta interaction protein, C14orf129, HSPC210,)
• NCBI Gene ID: 51527
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9P0R6
  UNIPROT ID#>>A0A024R6P6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

GSK3B interacting protein interacts with:

• TNFAIP3 interacting protein 2

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