ACTL6B, actin like 6B

ACTL6B, actin like 6B

• The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a subunit of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. This subunit may be involved in the regulation of genes by structural modulation of their chromatin, specifically in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

• Gene Synonyms (actin-like protein 6B, 53 kDa BRG1-associated factor B, BRG1-associated factor 53B, actin-related protein Baf53b, hArpN alpha, ACTL6, BAF53B, EIEE76, IDDSSAD, arpNalpha,)
• NCBI Gene ID: 51412
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O94805
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

actin like 6B interacts with:

• coenzyme Q9
  E1A binding protein p400
  H2B clustered histone 1
  pleckstrin homology domain containing A4
  solute carrier family 35 member A5
  solute carrier family 38 member 7

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.