PCDH12, protocadherin 12

PCDH12, protocadherin 12

• This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 6 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene localizes to the region on chromosome 5 where the protocadherin gene clusters reside. The exon organization of this transcript is similar to that of the gene cluster transcripts, notably the first large exon, but no significant sequence homology exists. The function of this cellular adhesion protein is undetermined but mouse protocadherin 12 does not bind catenins and appears to have no affect on cell migration or growth. [provided by RefSeq, Jul 2008]

• Gene Synonyms (protocadherin-12, VE-cad-2, VE-cadherin 2, vascular cadherin-2, vascular endothelial cadherin 2, DMJDS1, VE-cadherin-2, VECAD2,)
• NCBI Gene ID: 51294
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9NPG4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

protocadherin 12 interacts with:

• discoidin, CUB and LCCL domain containing 1
  protocadherin 10
  protocadherin gamma subfamily A, 11
  transmembrane O-mannosyltransferase targeting cadherins 4

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.