NOX4, NADPH oxidase 4

NOX4, NADPH oxidase 4

• This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]

• Gene Synonyms (NADPH oxidase 4, kidney oxidase-1, kidney superoxide-producing NADPH oxidase, renal NAD(P)H-oxidase, KOX, KOX-1, RENOX,)
• NCBI Gene ID: 50507
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B3KQ17
  UNIPROT ID#>>B7Z523
  UNIPROT ID#>>B7Z529
  UNIPROT ID#>>Q9NPH5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

NADPH oxidase 4 interacts with:

• actin beta like 2
  myosin XVIIIA
  signal regulatory protein alpha

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.