KIF7, kinesin family member 7

KIF7, kinesin family member 7

• This gene encodes a cilia-associated protein belonging to the kinesin family. This protein plays a role in the sonic hedgehog (SHH) signaling pathway through the regulation of GLI transcription factors. It functions as a negative regulator of the SHH pathway by preventing inappropriate activation of GLI2 in the absence of ligand, and as a positive regulator by preventing the processing of GLI3 into its repressor form. Mutations in this gene have been associated with various ciliopathies. [provided by RefSeq, Oct 2011]

• Gene Synonyms (ACLS, AGBK, HLS2, JBTS12, UNQ340, kinesin-like protein KIF7, EQYK340,)
• NCBI Gene ID: 374654
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q2M1P5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

kinesin family member 7 interacts with:

• coiled-coil domain containing 61

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.