TBX21, T-box transcription factor 21

TBX21, T-box transcription factor 21

• This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]

• Gene Synonyms (T-box transcription factor TBX21, T-box 21, T-box expressed in T cells, T-box protein 21, T-cell-specific T-box transcription factor T-bet, transcription factor TBLYM, T-PET, T-bet, TBET, TBLYM,)
• NCBI Gene ID: 30009
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UL17
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

T-box transcription factor 21 interacts with:

• zinc finger protein 490

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