SH3PXD2B, SH3 and PX domains 2B

SH3PXD2B, SH3 and PX domains 2B

• This gene encodes an adapter protein that is characterized by a PX domain and four Src homology 3 domains. The encoded protein is required for podosome formation and is involved in cell adhesion and migration of numerous cell types. Mutations in this gene are the cause of Frank-ter Haar syndrome (FTHS), and also Borrone Dermato-Cardio-Skeletal (BDCS) syndrome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]

• Gene Synonyms (SH3 and PX domain-containing protein 2B, adapter protein HOFI, adaptor protein HOFI, factor for adipocyte differentiation 49, tyrosine kinase substrate with four SH3 domains, FAD49, FTHS, HOFI, KIAA1295, TKS4, TSK4,)
• NCBI Gene ID: 285590
• Species: Homo sapiens (Human)
• UNIPROT ID#>>G3V144
  UNIPROT ID#>>A1X283
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

SH3 and PX domains 2B interacts with:

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.