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- Sequence Verification
GREM1, gremlin 1, DAN family BMP antagonist
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This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
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Gene Synonyms (gremlin-1, DAN domain family member 2, cell proliferation-inducing gene 2 protein, colorectal adenoma and carcinoma 1, cysteine knot superfamily 1, BMP antagonist 1, down-regulated in Mos-transformed cells protein, gremlin 1, cysteine knot superfamily, homolog, gremlin 1-like protein, hereditary mixed polyposis syndrome, increased in high glucose-2, C15DUPq, CKTSF1B1, CRAC1, CRCS4, DAND2, DRM, DUP15q, GREMLIN, HMPS, HMPS1, IHG-2, MPSH, PIG2,)
- NCBI Gene ID:
26585
- Species:
Homo sapiens (Human)
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UNIPROT ID#>>O60565
UNIPROT ID#>>B3KTR9
UNIPROT ID#>>A6XAA7
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for this Gene »
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gremlin 1, DAN family BMP antagonist interacts with:
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