CNTNAP2, contactin associated protein 2

CNTNAP2, contactin associated protein 2

• This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2, a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and intellectual disability. [provided by RefSeq, Jul 2017]

• Gene Synonyms (contactin-associated protein-like 2, cell recognition molecule Caspr2, contactin associated protein like 2, homolog of Drosophila neurexin IV, AUTS15, CASPR2, CDFE, NRXN4, PTHSL1,)
• NCBI Gene ID: 26047
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UHC6
  UNIPROT ID#>>A0A090N7T7
  UNIPROT ID#>>B2RCH4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

contactin associated protein 2 interacts with:

• zinc finger MIZ-type containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.