SUMF2, sulfatase modifying factor 2

SUMF2, sulfatase modifying factor 2

• The catalytic sites of sulfatases are only active if they contain a unique amino acid, C-alpha-formylglycine (FGly). The FGly residue is posttranslationally generated from a cysteine by enzymes with FGly-generating activity. The gene described in this record is a member of the sulfatase-modifying factor family and encodes a protein with a DUF323 domain that localizes to the lumen of the endoplasmic reticulum. This protein has low levels of FGly-generating activity but can heterodimerize with another family member - a protein with high levels of FGly-generating activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

• Gene Synonyms (inactive C-alpha-formylglycine-generating enzyme 2, C-alpha-formyglycine-generating enzyme 2, C-alpha-formylglycine-generating enzyme 2, epididymis secretory sperm binding protein, paralog of formylglycine-generating enzyme, paralog of the formylglycine-generating enzyme, pFGE,)
• NCBI Gene ID: 25870
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024RDK8
  UNIPROT ID#>>Q8NBJ7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

sulfatase modifying factor 2 interacts with:

• abhydrolase domain containing 11
  adenylate kinase 3
  ankyrin repeat domain 40
  cytochrome c oxidase assembly factor 4 homolog
  dynein 2 intermediate chain 2
  F-box and WD repeat domain containing 7
  fumarylacetoacetate hydrolase domain containing 1
  limb development membrane protein 1 like
  lysophospholipase like 1
  thioredoxin domain containing 12
  TP53 regulated inhibitor of apoptosis 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.