GABRA1, gamma-aminobutyric acid type A receptor subunit alpha1

GABRA1, gamma-aminobutyric acid type A receptor subunit alpha1

• This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (ECA4, EIEE19, EJM, EJM5, gamma-aminobutyric acid receptor subunit alpha-1, GABA(A) receptor subunit alpha-1, GABA(A) receptor, alpha 1, gamma-aminobutyric acid (GABA) A receptor, alpha 1, gamma-aminobutyric acid type A receptor alpha1 subunit,)
• NCBI Gene ID: 2554
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P14867
  UNIPROT ID#>>A8K177
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

gamma-aminobutyric acid type A receptor subunit alpha1 interacts with:

• heat shock protein 90 beta family member 1
  OS9 endoplasmic reticulum lectin
  protein kinase C delta
  protein kinase C gamma
  protein phosphatase 3 catalytic subunit alpha
  synoviolin 1
  ubiquilin 1
  valosin containing protein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.