NEIL2, nei like DNA glycosylase 2

NEIL2, nei like DNA glycosylase 2

• This gene encodes a member of the Fpg/Nei family of DNA glycosylases. These glycosylases initiate the first step in base excision repair by cleaving oxidatively damaged bases and introducing a DNA strand break via their abasic site lyase activity. This enzyme is primarily associated with DNA repair during transcription and acts prefentially on cytosine-derived lesions, particularly 5-hydroxyuracil and 5-hydroxycytosine. It contains an N-terminal catalytic domain, a hinge region, and a C-terminal DNA-binding domain with helix-two-turn-helix and zinc finger motifs. This enzyme interacts with the X-ray cross complementing factor 1 scaffold protein as part of a multi-protein DNA repair complex. A pseudogene of this gene has been identified. [provided by RefSeq, Mar 2017]

• Gene Synonyms (endonuclease 8-like 2, DNA glycosylase/AP lyase Neil2, DNA-(apurinic or apyrimidinic site) lyase Neil2, nei endonuclease VIII-like 2, nei homolog 2, nei-like protein 2, NEH2, NEI2,)
• NCBI Gene ID: 252969
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q969S2
  UNIPROT ID#>>A0A024R361
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

nei like DNA glycosylase 2 interacts with:

• agrin
  inhibitor of CDK, cyclin A1 interacting protein 1

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